FDA Names Dupixent as the First and Only Approved Drug to Treat Eosinophilic Esophagitis (EoE)

FDA Names Dupixent as the First and Only Approved Drug to Treat Eosinophilic Esophagitis (EoE)

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The U.S. Food and Drug Administration (FDA) announced the approval of Dupixent (dupilumab) to treat eosinophilic esophagitis (EoE) in adults and children ages 12 and older on May 21, 2022. The drug is the first and only treatment to be approved for EoE; Dupixent is already approved to treat atopic dermatitis (eczema), eosinophilic or oral steroid dependent asthma, and inadequately controlled chronic rhinosinusitis with nasal polyps.Jointly developed by Sanofi and Regeneron, dupilumab is a fully human monoclonal antibody that inhibits the signaling of the interleukin-4 and interleukin-13 pathways — it’s not an immunosuppressant.How Dupixent Treats Eosinophilic EsophagitisEoE is a chronic autoimmune disease in which a type of white blood cell, called eosinophil, builds up in the lining of the esophagus, the tube that connects the mouth to the stomach. The…
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Subvariants Are Fueling a Rise in COVID-19 Cases

Subvariants Are Fueling a Rise in COVID-19 Cases

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New data released by the Centers for Disease Control and Prevention (CDC) this week revealed that the BA.2.12.1 form of the coronavirus — a descendent of omicron — has quickly grown to surpass the BA.2 variant in the United States.For the week ending May 21, BA.2.12.1 accounted for almost 58 percent of new cases. BA.2 has dropped in prevalence to 39 percent. The original omicron variant, B1.1.529 — and its subvariant BA.1.1 that soon followed and dominated the United States in late January — now make up about 3 percent of cases.The BA.2.12.1 subvariant was first noticed in central New York and surrounding areas in mid-April, when the State Department of Health announced that BA.2.12.1 and BA.2.12 were contributing to local virus transmission, calling these variants “highly contagious.”These sub-subvariants have…
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Does the Stress of Student Loan Debt Negatively Impact Heart Health?

Does the Stress of Student Loan Debt Negatively Impact Heart Health?

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Years (or even decades) of monthly payments may not be the only downside to taking out a student loan. New research published May 3 in the American Journal of Preventive Medicine found that people who failed to pay down student debt, or who took on new educational debt, between young adulthood and early midlife had a higher risk of heart disease than those who never took out loans.More Than 45 Million Americans Are Paying Down Student LoansAs the cost of college has increased, students and their families have taken on more debt to get to and stay in college, says the study's lead author, Adam M. Lippert, PhD, a professor and researcher in the department of sociology at the University of Colorado in Denver.“Student debt has exploded in the country, with over…
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Experimental Drug Shows Early Potential to Treat Dementia

Experimental Drug Shows Early Potential to Treat Dementia

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Sodium selenate, an ingredient often included in vitamin supplements, appears safe to test as a treatment for dementia, the results of a preliminary study suggest.The safety study included 12 people with what’s known as behavioral variant frontotemporal dementia (bvFTD), a form of cognitive decline that can develop early in adulthood and lead to dramatic personality and behavior changes. People with this condition tend to behave in socially inappropriate ways and lack empathy, judgment, and self-control. There is currently no treatment for this rapidly progressing form of dementia, and people often die within a decade of diagnosis.All the patients took a 15 milligram (mg) dose of sodium selenate three times daily. The main goal of the yearlong study was to assess the drug's safety. While each participant experienced some side effects,…
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Best Buy Recalls Insignia Air Fryers and Air Fryer Ovens After Reports of Fires

Best Buy Recalls Insignia Air Fryers and Air Fryer Ovens After Reports of Fires

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Best Buy has recalled models of the Insignia Digital Air Fryers, Insignia Analog Air Fryers, and Insignia Digital Air Fryer Ovens because of 68 reports from U.S. consumers and 36 reports from Canadian consumers of the appliances catching fire, burning, or melting.The incidents included seven reports of minor property damage and two reports of injuries, including injury to a child’s leg, according to the United States Consumer Product Safety Commission. Consumers are advised to immediately stop using the recalled air fryers and ovens.It’s estimated that 635,000 Insignia air fryers and air fryer ovens were sold in the United States, and 137,000 in Canada between November 2018 and February 2022. The units cost between $30 and $150 and were purchased in stores and online at Best Buy, BestBuy.com, eBay.com and Google.com.Air…
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Cannabis Poisoning in Pets Is on the Rise

Cannabis Poisoning in Pets Is on the Rise

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The number of cannabis poisoning cases in pets — primarily dogs — has jumped significantly since 2018, according to a new Canadian study. Although most of the cases were mild, the research, published in PLoS One on April 20, found a small number of deaths attributable to marijuana ingestion.The psychoactive ingredient THC is primarily responsible for the euphoria or “high” that many people feel after using marijuana. It’s also what causes marijuana toxicosis (poisoning), which occurs when pets ingest the drug in any form.The rise in the number of poisonings appears to coincide with the legalization of marijuana in Canada, though it’s unclear whether the observed increase is due to increased prevalence or increased reporting, says Jibran Khokhar, PhD, a coauthor of the study and an assistant professor at Ontario Veterinary College at…
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Why Intermittent Fasting May Not Help When You’re Already Cutting Calories

Why Intermittent Fasting May Not Help When You’re Already Cutting Calories

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When it comes to weight loss, two diets may not be better than one. In a new study of people who cut calories to shed excess pounds, participants got similar results when they limited meals to certain hours of the day and when they ate anytime they wanted.For the study, researchers randomly assigned 118 people with obesity to limit how much they ate for one year — 1,500 to 1,800 calories for men and 1,200 to 1,500 calories for women. Half the participants were also asked to eat only between 8 a.m. and 4 p.m., while the rest of them could eat whenever they liked.People who ate only during certain hours, a practice known as intermittent fasting, lost an average of 8.0 kilograms (17.6 pounds) after one year, compared with…
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Ground Beef Recalled Nationwide Over Potential E. Coli Contamination

Ground Beef Recalled Nationwide Over Potential E. Coli Contamination

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More than 60 tons of ground beef are being pulled from stores across the country over concerns that the meat may be contaminated with E. coli bacteria, according to a U.S. Department of Agriculture’s (USDA) Food Safety and Inspection Service announcement on Monday.Distributed by the New Jersey–based Lakeside Refrigerated Services, the products under investigation include ground beef patties and loose ground beef sold at retailers, including Walmart and Winn-Dixie, under brand names such as Thomas Farms, Naturally Better, Nature’s Reserve, and Marketside Butcher. Several of the items are labeled “grass-fed” or “Wagyu.”All the meats subject to recall bear establishment number “EST. 46841” inside the USDA mark of inspection.The complete list of products and product codes (PDF) for the beef items that are subject to recall, as well as the labels for the…
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Asthma, Allergies Tied to an Increased Risk of Heart Disease

Asthma, Allergies Tied to an Increased Risk of Heart Disease

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If you have allergies or asthma — or have had these conditions in the past — you may be at increased risk of developing high blood pressure and coronary heart disease, preliminary results from a new study suggest.For the study, researchers examined survey data on more than 34,000 U.S. adults who were 49 years old on average, including about 10,000 people who reported a history of asthma or other allergic conditions like respiratory, digestive, or skin allergies. The data came from the 2012 National Health Interview Survey (NHIS).Overall, a history of asthma or allergic disorders was associated with a 45 percent higher risk of high blood pressure and a 48 percent greater risk of coronary heart disease. Asthma explained most of the increased risk.Among individuals with a history of asthma…
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